consultancy in computational toxicology

Applications: screening and chemical risk assessment

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Are you looking to build your skills in using approaches as read-across and QSAR? 

Join a training course. You will find public and in-house courses to learn the scientific basis of the approaches, how to predict chemical toxicity and how the methods are applied and assessed.

Are you looking to consolidate your knowledge working with our experts on your own projects?

Your solution is a learn-by-project approach, which includes training, software and consultancy.

Are you looking for experts in computational toxicology to more efficiently predict chemical toxicity? 

The incorporation of computational toxicology into risk assessment practices is an evolving area of high interest, but it also has some challenges ...

Computational or in silico toxicology

What is it?

It is a branch of toxicology concerned with the development and use of computer-based models to understand and predict the interactions of biological organisms (at population, individual, cellular, and molecular levels) with pollutants in the air, water, soil and food, and their adverse health effects that they may cause.

 

Why to use it?

Computational toxicology is a mean of reducing your in vivo and in vitro testing retaining the credibility of your chemical risk assessment in agreement with the 3Rs principles.

 

When to use it?

This multidisciplinary field has applications ranging from hazard and risk prioritization of chemicals to safety screening of drug metabolites, and has active participation and growth from many organizations, including government agencies, not-for-profit organizations, private industry, and universities.

 

As alternative to test data

  • Europe REACH (Annex XI of the European Union's REACH regulation and Globally Harmonized System of Classification and Labelling category

  • US Frank R. Lautenberg Chemical Safety for the 21st Century Act

  • US FDA CDRH (Centre for Devices and Radiological Health) guidance on medical devices and US FDA guidance on Electronic Nicotine Delivery Devices

 

As a part of the weight-of-evidence in regulatory submissions

 

When synthesis of a complex test material is not feasible

  • Mixture assessment

  • Assessment of impurities and degradation product

  • Residues of plat protection products

  • Assessment of extractable and leachables

  • Metabolites analysis

How to use it

You can choose the approach that best suits you among our services.

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