Endocrine Disruption Screening
Cleaning the Counter

ToxNavigation provides an in silico screening for endocrine disruption potential based on 153 models covering 18 receptors linked to the endocrine system.

The models that we employ include statistical-based and rule-based (Q)SAR as well as predictions based on docking to the 3D structure of the receptor. A wide selection of commercial and open source models are applied and all models are valid according to the OECD principles.

A free of cost feasibility study is conducted to ensure your compound is within the applicability domain of most models before accepting any contract.

The reliability of each prediction is assessed by an expert analysis and then the predictions are grouped by receptor to reach a consensus outcome. A detailed report is provided for a highly competitive price and can be used, as an example, under the Guidance for the identification of endocrine disruptors (ECHA and EFSA) in the context of the Biocidal Products Regulation (BPR, Regulation (EU) 528/2012).

For UVCB substances, ToxNavigation can enumerate justifiable representative structures of the UVCB by utilising cheminformatics before proceeding with the screening protocol.

The scientists at ToxNavigation have more than 25 years of experience in in silico modelling to predict the effects of chemicals on humans and in the environment and can generate reliable safety data in silico by combining results from (Q)SAR models, chemical categories, grouping and read-across


  • 25 years of experience with in silico  modelling

  • Multiple relevant models are used to increase confidence in the derived toxicity estimates

  • Expert selection of tools and methods in agreement with the official guidelines

  • In silico results complementary to in vitro results


  • Free feasibility study

  • In silico methods - lower cost compared to in vitro methods

  • Rapid access to several free and commercial tools

  • Service tailored to your needs (e.g. internal decision making or safety evaluation)


  • Feasibility study typically delivered in two days

  • Study report typically delivered within two weeks

  • 24 hour reactivity to client questions