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Endocrine Disruption Screening

Short oral presentation at the British Toxicology Society Congress 2022

Endocrine-disrupting chemicals are suspected to cause adverse effects in the endocrine system by interfering with the synthesis, transport, degradation, or action of endogenous ligands.

 

In 2018 a guidance describing how to perform hazard identification for endocrine-disrupting properties following the scientific criteria outlined in EU 2017/2100 and EU 2018/605 for biocidal products and plant protection products, respectively, was published by ECHA and EFSA. In this guidance computational approaches are proposed as line of evidence for endocrine activity assessment.

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ToxNavigation provides an in silico screening for endocrine disruption potential based on 117+ models linked to the endocrine system using both commercial and freely available tools. 
 

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All the models are applied and the results are combined. If the substance is included in the training set of a model, we use both the predictions and the experimental data. The results of the QSAR are rated according to the sensitivity of the model and the reliability of the prediction to consider both the uncertainty of the model itself and the uncertainty of the prediction.

 

The results of the profilers are primarily used to confirm the results of the QSAR as these approaches are known to give high rate of false positives.

 

If the final result is uncertain, a read-across can be applied.

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The process follows a defined protocol followed by an expert review and report.

poster

If you require Endocrine Disruption Screening or wish further information, please contact us: info@toxnavigation.com

experience

  • 25 years of experience with in silico  modelling

  • Multiple relevant models are used to increase confidence in the derived toxicity estimates

  • Expert selection of tools and methods in agreement with the official guidelines

  • In silico results complementary to in vitro results

COST EFFECTIVE & FLEXIBLE

  • Free feasibility study

  • In silico methods - lower cost compared to in vitro methods

  • Rapid access to several free and commercial tools

  • Service tailored to your needs (e.g. internal decision making or safety evaluation)

DELIVERY & CUSTOMER SUPPORT

  • Feasibility study typically delivered in two days

  • Study report typically delivered within two weeks

  • 24 hour reactivity to client questions

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