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New Approach Methodologies - (Q)SAR and read-across service
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A reduction of animal testing for safety assessment of chemicals is being actively encouraged by regulators with the New Approach Methodologies (NAMs). Consequently there is a growing use of in silico methods to support regulatory submissions.

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ToxNavigation provides a cost effective in silico toxicology service using (Q)SAR and read-across to estimate the toxicological effect of your substances.  

A free feasibility study is conducted prior to acceptance of your project to ensure there is experimental data available to support a reasonable hypothesis.

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ToxNavigation has provided in silico toxicology predictions for read-across using a weight of evidence approach both for mono-constituents as well as UVCBs

 

The typical workflow that ToxNavigation follows for read-across is described in the video below.
 

 

The standard report includes the read-across result, a prediction report for the target substance, the list of analogues, their evaluation and their experimental values used in assigning the final read-across prediction. The report is structured in line with the Read-Across Assessment Framework (RAAF).

A bespoke report is also available upon request.

 

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The scientists at ToxNavigation have more than 25 years of experience in in silico modelling to predict the effects of chemicals on humans and in the environment and can generate reliable safety data in silico by combining results from (Q)SAR models, chemical categories, grouping and read-across. 
 

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experience

  • 25 years of experience with in silico  modelling

  • Multiple relevant models are used to increase confidence in the derived toxicity estimates

  • Expert selection of tools and methods in agreement with the official guidelines

  • In silico results complementary to in vitro results

COST EFFECTIVE & FLEXIBLE

  • Free feasibility study

  • In silico methods - lower cost compared to in vitro methods

  • Rapid access to several free and commercial tools

  • Service tailored to your needs (e.g. internal decision making or safety evaluation)

DELIVERY & CUSTOMER SUPPORT

  • Feasibility study typically delivered in two days

  • Study report typically delivered within two weeks

  • 24 hour reactivity to client questions

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