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New Approach Methodologies
QSAR & Read-across


A reduction of animal testing for safety assessment of chemicals is being actively encouraged by regulators with the New Approach Methodologies (NAMs). Consequently there is a growing use of in silico methods to support regulatory submissions.

ToxNavigation provides a cost effective in silico toxicology service using (Q)SAR and read-across to estimate the toxicological effect of your substances.  


ToxNavigation has provided in silico toxicology predictions for read-across using a weight of evidence approach both for mono-constituents as well as UVCBs

The typical workflow that ToxNavigation follows for read-across is described in the video below.


The standard report includes the read-across result, a prediction report for the target substance, the list of analogues, their evaluation and their experimental values used in assigning the final read-across prediction. The report is structured in line with the Read-Across Assessment Framework (RAAF)

A bespoke report is also available upon request.

We are also experienced in the assessment of potential mutagenicity under the pharmaceutical ICH M7 regulations.


​The scientists at ToxNavigation have more than 25 years of experience in in silico modelling to predict the effects of chemicals on humans and in the environment and can generate reliable safety data in silico by combining results from (Q)SAR models, chemical categories, grouping and read-across.

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