For many toxicologists, the shift toward New Approach Methodologies (NAMs) feels like a moving target. Perhaps the most significant development recently is the QSAR Assessment Framework (QAF) . If you missed ECHA’s recent webinar on the topic, it is an essential watch for anyone involved in chemical risk assessment. Why the QAF Matters Now In silico data is no longer just a "supplement." However, with increased use comes increased scrutiny. The QAF provides the criteria regulatory agencies...

Ready to Master Genotoxicity Prediction? Understanding the uncertainties of reference data is the first step toward building more robust and scientifically sound NAM strategies. ToxNavigation is at the forefront of this shift. We are excited to announce the 2026  release of our new in-depth training course: "NAMs - QSAR and read-across to predict genotoxicity" This course is designed to equip expert toxicologists with the practical skills to apply in silico  methods for genotoxicity...

The U.S. Food and Drug Administration (FDA) has unveiled its Expanded Decision Tree (EDT) , a significant modernization of the classic Cramer Decision Tree. As toxicologists, we understand the increasing need for efficient, structure-based methods to screen the vast number of chemicals in the food supply, especially those with limited existing safety data. The EDT is the FDA's new tool for this, marking a step forward in the use of computational toxicology  (also known as in silico  methods)...