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Webinars on NAMs

Updated: Nov 24, 2021

ToxNavigation selection of webinars to keep up to date with the latest developments in NAMs. This is not intended to be a comprehensive list, but it is a good selection of available free webinars dedicated to NAMs scheduled in the next few months.


OECD QSAR Toolbox applications for REACH and beyond

30 November 2021 11:00 - 13:00 EET

The webinar presents the experience of different stakeholders using the QSAR Toolbox. After a status overview given by OECD, ECHA will present how the QSAR Toolbox results are used and assessed in different REACH processes. The webinar will continue with presentations from academia (Danish Technical University, DTU) and governmental organisations (Italian National Institute of Health, ISS; Environment and Climate Change Canada, ECCC; National Institute of Technology and Evaluation, NITE Japan) about their uses of the QSAR Toolbox.


New Approach Methodologies for Medical Devices

December 2, 2021 10:00 a.m. – 1:30 p.m. EST

December 3, 2021 10:00 a.m. – 1:30 p.m. EST

Use of New Approach Methodologies for the Biological Safety Assessment of Medical Devices. At this two-day event you will learn about how to qualify NAMs through CDRH’s Medical Devices Development Tools program, how to perform in silico chemical characterization, and how to use available in vitro methods for assessing irritancy, biocompatibility, pyrogenicity, and thrombogenicity. Don’t miss this chance to network with speakers and have your questions answered during our discussion panels.

Current Concepts in Quantitative Risk Assessment for Skin Sensitization:

Webinar 2: Methods for hazard and exposure assessment

December 8, 2021 9:00-10:30 a.m. EDT

Webinar 3: Opportunities and new approaches for quantitative risk assessment

March 9, 2022 9:00-10:30 a.m. EDT

Allergic contact dermatitis is one of the most frequent occupational diseases associated with chemical exposure. Chemicals and pesticides must be tested for their potential to cause skin sensitization and there have been major developments in testing strategies in recent years, as new approach methods are becoming accepted alternatives to traditional animal tests. Despite this progress, quantitative risk assessment of skin sensitizing chemicals remains a challenging process.

This webinar series will provide an overview of the current state of the science in this rapidly developing field. The webinars are intended as background for a planned workshop in 2022 on quantitative risk assessment of skin sensitizing pesticides but they are of interest to the broader scientific community as they are relying on the development of concepts and methods in other areas e.g. cosmetics, fragrances and consumer products.

Webinar 2: Methods for hazard and exposure assessment

  • Hazard assessment and potency determination using current non-animal test methods, Nicole Kleinstreuer, National Institute of Environmental Health Sciences

  • Exposure assessment and quantification, Denise Bloch, Federal Institute for Risk Assessment (Germany)

Webinar 3: Opportunities and new approaches for quantitative risk assessment (titles subject to change)

  • Quantitative risk assessment for skin sensitizing cosmetics and fragrances

  • The road ahead: future developments and methods still in the research phase

ECHA: Assessing groups of chemicals: what you need to know

14 December 2021 11:00 - 13:00 EET

It will be explained how ECHA assesses the regulatory needs of groups of substances and how this approach helps speed up regulatory action for substances of concern – and what information ECHA has started to publish to better inform companies and citizens about the foreseen action towards a safer use of chemicals.

Integrating Computational Tools into Carcinogenicity Assessments

Carcinogenesis Specialty Section (CSS) and Computational Toxicology Specialty Section (CTSS) Joint Webinar

December 14, 2021 10:00 AM ET

The webinar will explore computational tools and predictive models for assessing carcinogenicity as well as address opportunities to improve on current methods and increase their implementation in safety evaluations for drugs and potentially hazardous chemicals.

  • In Silico Methods for the Prediction of Carcinogenicity, Dr. Mark Cronin, PhD

  • The EURL ECVAM Curated Database of Genotoxicity & Carcinogenicity Results: Opportunities for Application in Regulatory Science, Dr. Federica Madia, PhD


Standardization of PBPK Modeling Practice

January 14, 2022, 12:00 Noon–1:00 PM ET

The development of physiologically-based pharmacokinetic (PBPK) models have grown steadily since their emergence. However, the lack of a standardized template for PBPK model coding and analysis reporting has considerably hindered the sharing, reusing, and reviewing of developed models and the acceptance of PBPK models as risk assessment tools by regulatory agencies. In this webinar, two speakers, Drs. Cecilia Tan and Paul Schlosser from US EPA, will share their recent efforts in the front of standardization of PBPK practice for environmental chemicals. Dr. Tan will present a harmonized reporting template that can be adopted and customized by public health agencies receiving PBPK model submission. The template can also serve as general guidance for submitting PBPK-related studies for publication in journals or other modeling sharing purposes. Dr. Schlosser will present a PBPK model coding template in the freely available R language by using a case study on per- and polyfluoroalkyl Substances. The template, once established and thoroughly reviewed for a class of compounds, will insulate subsequent reviewers from repeating the tedious process and allow them to only focus on the parameter inputs and exposure scenarios applied, thus making the review process more efficient and less error-prone. In summary, standardization of model coding and reporting will facilitate PBPK modeling as a risk assessment tool.


The 1st AOP Community of Practice Symposium

February 15, 17, and 22, 2022 Rotating start times to accommodate global participation

Are you interested in:

  • More effectively using scientific information in impactful decision-making?

  • Developing and publishing novel AOPs or contributing to existing AOPs?

  • Using AOPs to inform risk assessments, regulation, or policy setting?

  • Conducting research to fills critical gaps in existing understanding of biological systems?

  • Learning more about AOPs and their applications?

  • Shaping the evolution of the AOP framework and AOP-KB?

Download the full invitation here:

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