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New release of Session 4 of NAMs - Use and Applications of (Q)SAR and Read-Across


We are thrilled to announce the release of the new version of Session 4 of our eLearning course "NAMs - Use and Applications of (Q)SAR and Read-Across". This session, titled "Interpretation of (Q)SAR", offers comprehensive insights into the principles and frameworks essential for understanding and applying (Q)SAR models effectively.


This session is designed to provide you with the knowledge and tools necessary to critically evaluate (Q)SAR models and predictions, ensuring their effective application in regulatory and hazard assessment contexts. Whether you are a seasoned professional or new to the field, this course will enhance your understanding and capabilities in using (Q)SAR methodologies.


The course is recognised by EUROTOX for 16 hours of Continued Professional Development (CPD) for ERT accredited toxicologists.


Table of Contents of Session 4: Interpretation of (Q)SAR


1. Introduction

Get acquainted with the foundational concepts of (Q)SAR interpretation.


2. REACH Annex XI Principles for (Q)SAR Models

Explore the regulatory guidelines under REACH for (Q)SAR model validation.


3. The OECD Principles for the Validation of (Q)SAR Models

Understand the internationally recognized standards for (Q)SAR model validation.


4. (Q)SAR Assessment Framework: Model Checklist

Learn to systematically evaluate (Q)SAR models with a comprehensive checklist.

  • Introduction to the (Q)SAR Assessment Framework: An overview of the framework for assessing (Q)SAR models.

  • The Model Checklist: Detailed criteria to ensure the robustness and reliability of (Q)SAR models.

  • The Model Criteria: In-depth discussion of each criterion used in the model checklist.

  • The Model Criteria Mapped on the (Q)SAR Model Reporting Format (QMRF): How to apply the model criteria within the QMRF structure.


5. Sources of Uncertainty in (Q)SAR Predictions

Identify and describe the uncertainties associated with (Q)SAR predictions. Detailed analysis of potential uncertainties and their implications.


6. Annex XI Principles for Predictions

Principles guiding the interpretation and use of (Q)SAR predictions under Annex XI.


7. (Q)SAR Assessment Framework: Prediction Checklist

A checklist for assessing the reliability of (Q)SAR predictions.


8. (Q)SAR Assessment Framework: Assessment of a (Q)SAR Result Derived from Multiple Predictions

Strategies for integrating multiple (Q)SAR predictions for a comprehensive assessment.


9. Guidelines on the Use of (Q)SAR

Best practices for applying (Q)SAR predictions in regulatory contexts.

Concluding insights and recommendations for regulatory application of (Q)SAR.


10. QSAR Model Reporting Format QMRF v2.1

Overview of the updated QSAR Model Reporting Format.

Detailed breakdown of the QMRF structure and its components.


Demonstrations

Demonstration 4.1: QMRF and Model Checklist

Hands-on exercise to compile a model checklist using the QMRF of the "VEGA 48 hour Daphnia Magna LC50" model.


Demonstration 4.2: QPRF and Prediction Checklist

Practical example of preparing the QPRF and the QAF Prediction checklist for CAS 10032-02-7 using the Mutagenicity (Ames test) and skin sensitization models (CAESAR) in VEGA for internal hazard assessment.


We look forward to your participation and are excited to see how this session will enhance your proficiency in the use of (Q)SAR models.


Feel free to share this announcement with colleagues and professionals who might benefit from this updated session. For any questions or additional information, please do not hesitate to contact us.


To enroll in NAMs - Use and application of QSAR and read-across visit https://courses.toxnavigation.com/course/nams

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