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Fragrance Materials Safety Assessment Database


The Research Institute for Fragrance Materials (RIFM) has partnered with Elsevier on the Food and Chemical Toxicology Fragrance Material Safety Assessment Center to provide open access to RIFM’s peer-reviewed Safety Assessments and related papers and research.


RIFM Safety Assessments are written according to the guidelines outlined in the Criteria for the Research Institute for Fragrance Materials (the “Criteria Document”) safety evaluation process for fragrance ingredients. The Criteria Document provides guidance on conducting safety assessments and is designed to incorporate the best science to appropriately evaluate fragrance ingredients using the latest testing strategies and methods, including read-across, in vitro / in silico methods and exposure threshold. Link to the database


Criteria for the Research Institute for Fragrance Materials, Inc. (RIFM) safety evaluation process for fragrance ingredients

Step 1: Look for available data and determine adequacy Step 2: Read-across data or in vitro/ in silico methods Step 3: Exposure Threshold Step 4: Generate Required Data (on material, metabolic pathway, or analogue to build a read-across structure)


If you want to learn how to carry out a read-across or to use a QSAR prediction for regulatory applications: ToxNavigation tutor-assisted eLearning course "NAMs - Use and application of QSAR and read-across".

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