• Elena Fioravanzo

Toxicokinetics and read-across


This open-access paper (https://doi.org/10.1016/j.yrtph.2018.08.006) is a great overview on ongoing scientific activities in various sectors addressing the availability and the possible use of toxicolkinetics data to support read-across.


Abstract: The European Partnership for Alternative Approaches to Animal Testing (EPAA) convened a Partners' Forum Toxicokinetics and Read-Acrossto provide an overview on research activities to develop in vitro toxicokinetics methods and physiologically-based kinetic (PBK) models and to find synergies to enhance use of toxicokinetic data to strengthen read-across. Currently, lacking toxicokinetic data often prevent the application of read-across. Preferably, toxicokinetic data should be generated using in vitro and in silico tools and anchored towards human relevance.....


Paragraphs:

Toxicokinetics strategy at the JRC and ongoing activities of the OECD

Ongoing sectorial activities:

- Pharmaceuticals and vaccines sector input

- Cosmetics sector input

- Fragrances sector input

- Agrochemicals sector input

- Chemicals sector input

Activities of the EC, EU agencies and multilateral research initiatives


Conclusions and recommendations

As an outcome of the EPAA Partners' Forum Finding synergies for 3Rs – toxicokinetics and read-across, the following conclusions were made: