Toxicokinetics and read-across
This open-access paper (https://doi.org/10.1016/j.yrtph.2018.08.006) is a great overview on ongoing scientific activities in various sectors addressing the availability and the possible use of toxicolkinetics data to support read-across.
Abstract: The European Partnership for Alternative Approaches to Animal Testing (EPAA) convened a Partners' Forum Toxicokinetics and Read-Acrossto provide an overview on research activities to develop in vitro toxicokinetics methods and physiologically-based kinetic (PBK) models and to find synergies to enhance use of toxicokinetic data to strengthen read-across. Currently, lacking toxicokinetic data often prevent the application of read-across. Preferably, toxicokinetic data should be generated using in vitro and in silico tools and anchored towards human relevance.....
Toxicokinetics strategy at the JRC and ongoing activities of the OECD
Ongoing sectorial activities:
- Pharmaceuticals and vaccines sector input
- Cosmetics sector input
- Fragrances sector input
- Agrochemicals sector input
- Chemicals sector input
Activities of the EC, EU agencies and multilateral research initiatives
Conclusions and recommendations
As an outcome of the EPAA Partners' Forum Finding synergies for 3Rs – toxicokinetics and read-across, the following conclusions were made: