• Elena Fioravanzo

Say your thoughts about the AOP framework


ToxNavigation promotes the dissemination of the survey. A message from Stonehaven Consulting AG for European Commission Joint Research Centre, Chemical Safety and Alternative Methods Unit.


Say your thoughts


The recent Global Chemicals Outlook II report of the United Nations Environment Programme has recommended that stakeholders "accelerate development of the concept of Adverse Outcome Pathways (AOPs) to support hazard assessment". An AOP is a means to organise mechanistic knowledge about toxicological processes to support various aspects of chemical hazard assessment including making better use of mechanistic information derived from non-animal methods in decision making. Since 2012, the Organisation for Economic Development and Cooperation (OECD) has been running the AOP programme to promote the concept, support the development AOPs of regulatory relevance, and to exploit AOP knowledge in, for example, Integrated Approaches to Testing and Assessment (IATA).


This is the right moment to take a step back and assess the impact the AOP framework has had in the past and can have in the future. The Adverse Outcome Pathways (AOP) Framework Study engages with stakeholders in chemicals assessment, management, and regulation, in industry and governance. The first aim of this research is to gain a better understanding of the needs of these stakeholders as users, or potential users of mechanistic data, or mode of action data. Ultimately, the aim is to make the AOP Framework and Knowledge Base more responsive to stakeholder needs, and to increase its usability and efficiency in supporting decision making about chemicals with relevant and robust scientific evidence.


The survey is a part of the study. It is an opportunity to let us know your thoughts about non-animal mechanistic approaches, and only about 10 minutes to fill in. Besides the survey, the study includes interviews and focus groups, some of which are conducted at Chemical Watch events.


This research is conducted by Stonehaven Consulting AG for European Commission Joint Research Centre, Chemical Safety and Alternative Methods Unit.


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