• Elena Fioravanzo

Read the results of the Ames/QSAR International Challenge Project

The Division of Genetics and Mutagenesis, National Institute of Health Sciences (DGM/NIHS) of Japan recently established a unique proprietary Ames mutagenicity database containing 12140 new chemicals that have not been previously used for developing QSAR models. The DGM/NIHS provided this Ames database to QSAR vendors to validate and improve their QSAR tools. The Ames/QSAR International Challenge Project was initiated in 2014 with 12 QSAR vendors testing 17 QSAR tools against these compounds in three phases. Now the final results are presented in a paper.

In Phase I ToxGPS was rated among the first 4 out of 18 in terms of Sensitivity, which measures the ability of a QSAR tool to detect strong Ames positives compounds correctly. To know more about ToxGPS, its approaches for genotoxicity, and applications for ICH M7, please contact me at elena@toxnavigation.com.

Read the full paper here.