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NC3Rs Workshop on Application of Non-Animal Approaches

There is still time to register to the workshop Application of non-animal approaches for decision-making in chemical safety assessment organized by NC3Rs in collaboration with Unilever in central London on 10-11 December 2018. Attendance is free, but registration is essential. The closing date for registration is 26 November 2018.

If you are attending and you would like to know more on what we do in this area, please feel free to drop me an e-mail in advance (

We have submitted a poster abstract on our recent studies in building a more robust read-across approach to reduce uncertainty by identifying analogues that are biologically meaningful and relevant to the target toxicity endpoints and combining available information by applying a weight of evidence method to predict the outcome and estimate uncertainties.

The key objectives of the workshop are to:

  • Showcase how non-animal approaches (i.e. in vitro and in silico) are currently being used to enable and improve decision-making for chemical safety assessment, including the use of AOPs/mechanistic approaches and incorporation of exposure science.

  • Increase awareness and acceptance of non-animal approaches to accelerate their uptake to support decision-making, particularly in a regulatory setting.

  • Identify scientific gaps that if addressed could have a significant impact on the application and uptake of non-animal approaches.

  • Encourage collaboration between sectors, to share knowledge and ‘lessons learned’ to maximise the impact of non-animal approaches and to improve safety and efficacy decision-making.

The workshop will be chaired by Professor Ian Kimber OBE, Professor of Toxicology at the University of Manchester. Discussions will focus on what is needed to give ‘comfort’ and confidence in these new approaches to make decisions for safety assessment.

Confirmed speakers include:

Dr Paul Andrews, SimOmics, UK

Dr Warren Casey, NICEATM, USA

Dr Rebecca Clewell, 21st Century Tox Consulting, USA

Dr Joshua Harrill, U.S. Environmental Protection Agency, USA

Dr Delyan Ivanov, AstraZeneca, UK

Dr Hans Ketelslegers, Concawe, Belgium

Dr Robert Landsiedel, BASF, Germany

Dr Donna Macmillan, Lhasa Limited, UK

Dr Luigi Margiotta-Casaluci, Brunel University, UK

Dr Tina Mehta, Adama, UK

Professor Aldert Piersma, RIVM, The Netherlands

Dr Tomasz Sobanski, ECHA, Finland

Professor Mathieu Vinken, Vrije Universiteit Brussel, Belgium

Dr Carl Westmoreland, Unilever, UK

Professor Maurice Whelan, JRC, Italy

Professor Martin Wilks, Swiss Centre for Applied Human Toxicology, Switzerland

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