Non-testing methods for Dietary Risk Assessment of Plant Protection Products and their Residues

The Guidance on the establishment of the residue definition for dietary risk assessment adopted by EFSA in 2016  describes a stepwise approach based on toxicological, metabolism and non-testing data ((Q)SAR, read-across and TTC ) to:

  • conclude for which of the residues of a pesticide on food and feed commodities a hazard identification and characterisation is needed;

  • perform such a hazard identification and characterisation;

  • The usefulness of in silico methods as an alternative to testing chemical toxicity in animals has been recognised both by industry and regulators worldwide. 


The scientists at ToxNavigation have more than 25 years of experience in in silico modelling to predict the effects of chemicals on humans and in the environment and can generate reliable toxicity data in silico by combining results from (Q)SAR models, chemical categories, grouping and read-across

(Q)SAR and read-across

Grouping of metabolites

Genotoxicity profiling

Assessment of general toxicity

Grouping of metabolites

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