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Non-testing methods for Dietary Risk Assessment of Plant Protection Products and their Residues

The Guidance on the establishment of the residue definition for dietary risk assessment adopted by EFSA in 2016  describes a stepwise approach based on toxicological, metabolism and non-testing data ((Q)SAR, read-across and TTC ) to:

  • conclude for which of the residues of a pesticide on food and feed commodities a hazard identification and characterisation is needed;

  • perform such a hazard identification and characterisation;

  • The usefulness of in silico methods as an alternative to testing chemical toxicity in animals has been recognised both by industry and regulators worldwide. 


The scientists at ToxNavigation have more than 25 years of experience in in silico modelling to predict the effects of chemicals on humans and in the environment and can generate reliable toxicity data in silico by combining results from (Q)SAR models, chemical categories, grouping and read-across

(Q)SAR and read-across

Grouping of metabolites

Genotoxicity profiling

Assessment of general toxicity

Grouping of metabolites


  • 25 years of experience with in silico  modelling

  • Multiple relevant models are used to increase confidence in the derived toxicity estimates

  • Expert selection of tools and methods in agreement with the official guidelines

  • In silico results complementary to in vitro results


  • Free feasibility study

  • In silico methods - lower cost compared to in vitro methods

  • Rapid access to several free and commercial tools

  • Service tailored to your needs (e.g. internal decision making or safety evaluation)


  • Feasibility study typically delivered in two days

  • Study report typically delivered within two weeks

  • 24 hour reactivity to client questions

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