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Customization
Integration of ToxGPS, ChemTunes and Corina technology into your chemoinformatics environment
Customization
Integration of ToxGPS, ChemTunes and Corina technology into your chemoinformatics environment
Customization
Integration of ToxGPS, ChemTunes and Corina technology into your chemoinformatics environment
training, consultancy and software for computational toxicology
Read-Across Assessment Framework (RAAF) Considerations on multi-constituent substances and UVCBs
Technical report collection
2017
REACH, read-across, RAAF, UVCB
ECHA
The focus of the Read-Across Assessment Framework (RAAF) published in May 2015 is on mono-constituent substances. Although the assessment framework may also be applied in an analogous manner to multi-constituent substances and ‘substances of unknown or variable composition, complex reaction products or biological materials (UVCBs)’, ECHA considered that additional issues need to be addressed when read-across cases involving such substances have to be assessed. The first step towards a future extension of the RAAF is to identify such additional issues emerging in readacross cases involving multi-constituent substances and/or UVBCs. This document describes the additional key issues for the ECHA experts assessing such cases. Such considerations may also be relevant for registrants in the justification of read-across cases. However, due to the case-specific nature of read-across cases for multi-constituent substances and/or UVCBs, the document does not provide considerations on how to deal with the identified issues when adaptations using readacross are developed.